Assay Detail
Binding
CHEMBL880145
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Binding affinity towards human mutant NK-1 receptor in which His-197 has been replaced by alanine (H197A)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Quinuclidine-based NK1 antagonists, the role of the benzhydryl
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.15 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283356 | L-706125 | — | 1 | 6.71 |
| CHEMBL22194 | L-709210 | — | 1 | 6.48 |
| CHEMBL282657 | — | — | 1 | 6.30 |
| CHEMBL435564 | — | — | 1 | 6.21 |
| CHEMBL283979 | — | — | 1 | 6.07 |
| CHEMBL277260 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283356 | L-706125 | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL22194 | L-709210 | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL282657 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL435564 | — | IC50 | = | 615.0 | nM | 6.21 |
| CHEMBL283979 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL277260 | — | IC50 | = | 7500.0 | nM | 5.12 |