Assay Detail
Functional
CHEMBL880195
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The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Flavonoids: structural requirements for antiproliferative activity on breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.59 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | — | 1 | 4.79 |
| CHEMBL319911 | — | — | 1 | 4.74 |
| CHEMBL104255 | FLAVOKAWAIN B | — | 1 | 4.70 |
| CHEMBL319918 | — | — | 1 | 4.65 |
| CHEMBL317469 | — | — | 1 | 4.57 |
| CHEMBL75267 | 7,8-DIHYDROXYFLAVONE | — | 1 | 4.56 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | — | 1 | 4.55 |
| CHEMBL104575 | — | — | 1 | 4.54 |
| CHEMBL317869 | — | — | 1 | 4.45 |
| CHEMBL9687 | — | — | 1 | 4.45 |
| CHEMBL107131 | DIMETHYLPINOCEMBRIN | — | 1 | 4.44 |
| CHEMBL317221 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL319911 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL104255 | FLAVOKAWAIN B | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL319918 | — | IC50 | = | 22200.0 | nM | 4.65 |
| CHEMBL317469 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL75267 | 7,8-DIHYDROXYFLAVONE | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL104575 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL317869 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL9687 | — | IC50 | = | 35700.0 | nM | 4.45 |
| CHEMBL107131 | DIMETHYLPINOCEMBRIN | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL317221 | — | IC50 | > | 60000.0 | nM | - |