Assay Detail
Binding
CHEMBL880240
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Displacement of [3H]LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.41 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414668 | — | — | 1 | 8.70 |
| CHEMBL364005 | — | — | 1 | 8.13 |
| CHEMBL193351 | — | — | 1 | 8.00 |
| CHEMBL194843 | — | — | 1 | 7.52 |
| CHEMBL195759 | — | — | 1 | 7.52 |
| CHEMBL363417 | — | — | 1 | 7.40 |
| CHEMBL365751 | — | — | 1 | 7.40 |
| CHEMBL435126 | — | — | 1 | 7.40 |
| CHEMBL364271 | — | — | 1 | 7.30 |
| CHEMBL371203 | — | — | 1 | 7.22 |
| CHEMBL370436 | — | — | 1 | 7.16 |
| CHEMBL194305 | — | — | 1 | 7.10 |
| CHEMBL18785 | RU-24969 | — | 1 | 7.10 |
| CHEMBL195239 | — | — | 1 | 7.00 |
| CHEMBL194908 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414668 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL364005 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL193351 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL194843 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL195759 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL363417 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL365751 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL435126 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL364271 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL371203 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL370436 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL194305 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL18785 | RU-24969 | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL195239 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL194908 | — | IC50 | = | 600.0 | nM | 6.22 |