Assay Detail
Binding
CHEMBL880241
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In vitro concentration required to inhibit the overall HIV-1 integrase strand transfer
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.27 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414850 | — | — | 1 | 9.30 |
| CHEMBL198001 | — | — | 1 | 8.70 |
| CHEMBL194735 | — | — | 1 | 8.00 |
| CHEMBL196689 | — | — | 1 | 7.77 |
| CHEMBL196391 | — | — | 1 | 7.72 |
| CHEMBL186820 | — | — | 1 | 7.70 |
| CHEMBL194241 | — | — | 1 | 6.82 |
| CHEMBL363170 | — | — | 1 | 6.70 |
| CHEMBL197001 | — | — | 1 | 6.66 |
| CHEMBL372325 | — | — | 1 | 6.66 |
| CHEMBL365604 | — | — | 1 | 6.41 |
| CHEMBL362916 | — | — | 1 | 6.12 |
| CHEMBL197554 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414850 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL198001 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL194735 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL196689 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL196391 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL186820 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL194241 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL363170 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL197001 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL372325 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL365604 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL362916 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL197554 | — | IC50 | = | 1200.0 | nM | 5.92 |