Assay Detail
Binding
CHEMBL880243
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Inhibitory concentration against Trypanosoma cruzi farnesyl pyrophosphate synthase (TcFPPS)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.28 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198510 | — | — | 1 | 6.42 |
| CHEMBL55264 | — | — | 1 | 5.71 |
| CHEMBL372556 | — | — | 1 | 5.45 |
| CHEMBL194624 | — | — | 1 | 5.41 |
| CHEMBL194557 | — | — | 1 | 4.51 |
| CHEMBL371748 | — | — | 1 | 4.18 |
| CHEMBL196578 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198510 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL55264 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL372556 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL194624 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL194557 | — | IC50 | = | 30770.0 | nM | 4.51 |
| CHEMBL371748 | — | IC50 | = | 66650.0 | nM | 4.18 |
| CHEMBL196578 | — | IC50 | = | 149590.0 | nM | - |