Assay Detail
Binding
CHEMBL880272
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Inhibitory concentration against human placental cytochrome P450 19A1 using [1-beta-3H]-androstenedione as substrate
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.93 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 7.52 |
| CHEMBL194472 | — | — | 1 | 6.89 |
| CHEMBL362968 | — | — | 1 | 6.23 |
| CHEMBL381014 | — | — | 1 | 6.01 |
| CHEMBL438802 | — | — | 1 | 5.90 |
| CHEMBL197576 | — | — | 1 | 5.74 |
| CHEMBL195996 | — | — | 1 | 5.55 |
| CHEMBL365735 | — | — | 1 | 5.24 |
| CHEMBL193343 | — | — | 1 | 5.18 |
| CHEMBL196328 | — | — | 1 | 5.04 |
| CHEMBL195571 | — | — | 1 | - |
| CHEMBL193534 | — | — | 1 | - |
| CHEMBL196796 | — | — | 1 | - |
| CHEMBL371430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL194472 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL362968 | — | IC50 | = | 586.0 | nM | 6.23 |
| CHEMBL381014 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL438802 | — | IC50 | = | 1252.0 | nM | 5.90 |
| CHEMBL197576 | — | IC50 | = | 1805.0 | nM | 5.74 |
| CHEMBL195996 | — | IC50 | = | 2821.0 | nM | 5.55 |
| CHEMBL365735 | — | IC50 | = | 5727.0 | nM | 5.24 |
| CHEMBL193343 | — | IC50 | = | 6638.0 | nM | 5.18 |
| CHEMBL196328 | — | IC50 | = | 9107.0 | nM | 5.04 |
| CHEMBL195571 | — | IC50 | > | 36000.0 | nM | - |
| CHEMBL193534 | — | IC50 | > | 36000.0 | nM | - |
| CHEMBL196796 | — | IC50 | > | 36000.0 | nM | - |
| CHEMBL371430 | — | IC50 | > | 36000.0 | nM | - |