Assay Detail
Binding
CHEMBL880414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Lysophosphatidic acid acyltransferase-beta enzyme over-expressed in Sf9 insect cell membrane
21
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (CHEMBL4772) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diamino-C,N-diarylpyridine positional isomers as inhibitors of lysophosphatidic acid acyltransferase-beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.35 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308945 | — | — | 1 | 7.77 |
| CHEMBL193874 | — | — | 1 | 7.40 |
| CHEMBL195457 | — | — | 2 | 7.35 |
| CHEMBL193911 | — | — | 1 | 7.30 |
| CHEMBL194604 | — | — | 1 | 7.30 |
| CHEMBL306107 | — | — | 1 | 7.27 |
| CHEMBL193588 | — | — | 1 | 7.00 |
| CHEMBL193589 | — | — | 2 | 6.85 |
| CHEMBL193713 | — | — | 1 | 6.62 |
| CHEMBL194603 | — | — | 1 | 6.58 |
| CHEMBL193910 | — | — | 1 | 6.31 |
| CHEMBL309753 | — | — | 2 | 5.70 |
| CHEMBL372358 | — | — | 1 | 5.19 |
| CHEMBL75561 | — | — | 1 | 5.16 |
| CHEMBL193879 | — | — | 1 | 4.75 |
| CHEMBL193878 | — | — | 1 | 4.54 |
| CHEMBL194167 | — | — | 2 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308945 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL193874 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL195457 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL193911 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL194604 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL306107 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL195457 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL193588 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL193589 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL193713 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL193589 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL194603 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL193910 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL309753 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL309753 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL372358 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL75561 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL193879 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL193878 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL194167 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL194167 | — | IC50 | > | 40000.0 | nM | - |