Assay Detail
Binding
CHEMBL880429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for displacement of [33P]-labeled S1P from human sphingosine 1-phosphate receptor 1 expressed in CHO cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.56 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198976 | — | — | 1 | 9.40 |
| CHEMBL381872 | — | — | 1 | 9.40 |
| CHEMBL194419 | — | — | 1 | 9.22 |
| CHEMBL195014 | — | — | 1 | 9.10 |
| CHEMBL198415 | — | — | 1 | 9.05 |
| CHEMBL194578 | — | — | 1 | 8.89 |
| CHEMBL372066 | — | — | 1 | 8.89 |
| CHEMBL196534 | — | — | 1 | 8.85 |
| CHEMBL195025 | — | — | 1 | 8.77 |
| CHEMBL196357 | — | — | 1 | 8.74 |
| CHEMBL194898 | — | — | 1 | 8.66 |
| CHEMBL193789 | — | — | 1 | 8.54 |
| CHEMBL366181 | — | — | 1 | 8.42 |
| CHEMBL195141 | — | — | 1 | 8.42 |
| CHEMBL371985 | — | — | 1 | 8.35 |
| CHEMBL371743 | — | — | 1 | 8.29 |
| CHEMBL364899 | — | — | 1 | 8.09 |
| CHEMBL197502 | — | — | 1 | 7.57 |
| CHEMBL371670 | — | — | 1 | 7.54 |
| CHEMBL196149 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198976 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL381872 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL194419 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL195014 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL198415 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL194578 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL372066 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL196534 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL195025 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL196357 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL194898 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL193789 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL366181 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL195141 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL371985 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL371743 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL364899 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL197502 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL371670 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL196149 | — | IC50 | = | 100.0 | nM | 7.00 |