Assay Detail
Binding
CHEMBL880573
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Inhibition of [3H]-AVP binding to human V2 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.51 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49429 | LIXIVAPTAN | 3.0 | 1 | 9.00 |
| CHEMBL196737 | — | — | 1 | 7.24 |
| CHEMBL380579 | — | — | 1 | 7.02 |
| CHEMBL424663 | — | — | 1 | 6.52 |
| CHEMBL381248 | — | — | 1 | 6.41 |
| CHEMBL197616 | — | — | 1 | 6.29 |
| CHEMBL198931 | — | — | 1 | 5.70 |
| CHEMBL372766 | — | — | 1 | 5.60 |
| CHEMBL371055 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49429 | LIXIVAPTAN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL196737 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL380579 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL424663 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL381248 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL197616 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL198931 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL372766 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL371055 | — | IC50 | = | 15000.0 | nM | 4.82 |