Assay Detail
Binding
CHEMBL880698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against recombinant human dihydrofolate reductase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.06 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318721 | — | — | 1 | 8.18 |
| CHEMBL100239 | — | — | 1 | 6.21 |
| CHEMBL83547 | — | — | 1 | 6.03 |
| CHEMBL329985 | — | — | 1 | 5.70 |
| CHEMBL328827 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318721 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL100239 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL83547 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL329985 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL328827 | — | IC50 | = | 70000.0 | nM | 4.16 |