Assay Detail
Functional
CHEMBL880832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxic activity required to inhibit murine lymphocytotic leukemia L1210 cell line
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
A new generation of N-aryl-N'-(1-alkyl-2-chloroethyl)ureas as microtubule disrupters: synthesis, antiproliferative activity, and beta-tubulin alkylation kinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.09 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423394 | — | — | 1 | 6.10 |
| CHEMBL148361 | — | — | 1 | 6.05 |
| CHEMBL150008 | — | — | 1 | 5.77 |
| CHEMBL145811 | — | — | 1 | 5.77 |
| CHEMBL356033 | — | — | 1 | 5.70 |
| CHEMBL358165 | — | — | 1 | 5.70 |
| CHEMBL148690 | — | — | 1 | 5.54 |
| CHEMBL146303 | — | — | 1 | 5.48 |
| CHEMBL149179 | — | — | 1 | 5.47 |
| CHEMBL357489 | — | — | 1 | 5.44 |
| CHEMBL423213 | — | — | 1 | 5.38 |
| CHEMBL435623 | — | — | 1 | 5.38 |
| CHEMBL149175 | — | — | 1 | 5.30 |
| CHEMBL146268 | — | — | 1 | 5.20 |
| CHEMBL146242 | — | — | 1 | 4.96 |
| CHEMBL146613 | — | — | 1 | 4.92 |
| CHEMBL149180 | — | — | 1 | 4.92 |
| CHEMBL358809 | — | — | 1 | 4.85 |
| CHEMBL344111 | — | — | 1 | 4.77 |
| CHEMBL148438 | — | — | 1 | 4.77 |
| CHEMBL149176 | — | — | 1 | 4.77 |
| CHEMBL148563 | — | — | 1 | 4.75 |
| CHEMBL149503 | — | — | 1 | 4.70 |
| CHEMBL434698 | — | — | 1 | 4.62 |
| CHEMBL149267 | — | — | 1 | 4.55 |
| CHEMBL146586 | — | — | 1 | 4.39 |
| CHEMBL150060 | — | — | 1 | 4.33 |
| CHEMBL356185 | — | — | 1 | 4.06 |
| CHEMBL146600 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423394 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL148361 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL150008 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL145811 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL356033 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL358165 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL148690 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL146303 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL149179 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL357489 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL423213 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL435623 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL149175 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL146268 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL146242 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL146613 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL149180 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL358809 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL344111 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL148438 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL149176 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL148563 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL149503 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL434698 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL149267 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL146586 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL150060 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL356185 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL146600 | — | IC50 | = | 90000.0 | nM | 4.05 |