Assay Detail
Binding
CHEMBL880850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards cloned neurokinin 1 receptor, based on the displacement of [125I]-labeled substance P
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Identification of L-tryptophan derivatives with potent and selective antagonist activity at the NK1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.80 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | — | 1 | 9.40 |
| CHEMBL22870 | L-732138 | — | 1 | 8.80 |
| CHEMBL282290 | — | — | 1 | 8.57 |
| CHEMBL278849 | L-709400 | — | 1 | 8.10 |
| CHEMBL278351 | — | — | 1 | 7.66 |
| CHEMBL23926 | — | — | 1 | 7.52 |
| CHEMBL26336 | — | — | 1 | 7.21 |
| CHEMBL23129 | L-708568 | — | 1 | 7.17 |
| CHEMBL23597 | — | — | 1 | 7.06 |
| CHEMBL23851 | — | — | 1 | 6.99 |
| CHEMBL281804 | — | — | 1 | 6.90 |
| CHEMBL24549 | — | — | 1 | 6.88 |
| CHEMBL280422 | — | — | 1 | 6.86 |
| CHEMBL23822 | — | — | 1 | 6.82 |
| CHEMBL281194 | — | — | 1 | 6.74 |
| CHEMBL283989 | — | — | 1 | 6.71 |
| CHEMBL279500 | — | — | 1 | 6.61 |
| CHEMBL24314 | — | — | 1 | 6.55 |
| CHEMBL429395 | — | — | 1 | 6.38 |
| CHEMBL23077 | — | — | 1 | 6.36 |
| CHEMBL23715 | — | — | 1 | 6.26 |
| CHEMBL23927 | — | — | 1 | 6.22 |
| CHEMBL23928 | — | — | 1 | 6.12 |
| CHEMBL279916 | — | — | 1 | 5.98 |
| CHEMBL279050 | — | — | 1 | 5.81 |
| CHEMBL23184 | — | — | 1 | 5.67 |
| CHEMBL26623 | — | — | 1 | 5.42 |
| CHEMBL2114308 | — | — | 1 | 5.26 |
| CHEMBL282728 | — | — | 1 | 5.26 |
| CHEMBL278555 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16192 | CP-96345 | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL22870 | L-732138 | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL282290 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL278849 | L-709400 | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL278351 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL23926 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL26336 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL23129 | L-708568 | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL23597 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL23851 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL281804 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL24549 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL280422 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL23822 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL281194 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL283989 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL279500 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL24314 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL429395 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL23077 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL23715 | — | IC50 | = | 553.0 | nM | 6.26 |
| CHEMBL23927 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL23928 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL279916 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL279050 | — | IC50 | = | 1533.0 | nM | 5.81 |
| CHEMBL23184 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL26623 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2114308 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL282728 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL278555 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL279915 | — | IC50 | > | 100.0 | nM | - |