Assay Detail
Binding
CHEMBL880876
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Dissociation constant for Retinoid X receptor alpha
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Ligand recognition by RAR and RXR receptors: binding and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.24 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75133 | IRX-4204 | 2.0 | 1 | 9.40 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.82 |
| CHEMBL32505 | — | — | 1 | 7.50 |
| CHEMBL308377 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75133 | IRX-4204 | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL705 | ALITRETINOIN | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL32505 | — | Kd | = | 32.0 | nM | 7.50 |
| CHEMBL308377 | — | Kd | = | 60.0 | nM | 7.22 |