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Assay Detail

CHEMBL880944

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human Tachykinin receptor 1
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Substance-P receptor (CHEMBL249)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Phenyl-glycinol based NK1 receptor antagonists towards the minimum pharmacophore
Owens A, Williams B, Harrison T, Swain C, Baker R, Sadowski S, Cascieri M
Bioorg Med Chem Lett (1995) 5 : 2761 -2766
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.69 8.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL93243 1 8.37
CHEMBL327765 1 8.24
CHEMBL323128 2 8.15
CHEMBL329105 1 8.10
CHEMBL92818 1 7.89
CHEMBL273302 1 7.86
CHEMBL329325 1 7.70
CHEMBL92524 1 7.52
CHEMBL92032 1 7.31
CHEMBL71498 1 7.26
CHEMBL93909 1 6.87

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL93243 IC50 = 4.3 nM 8.37
CHEMBL327765 IC50 = 5.8 nM 8.24
CHEMBL323128 IC50 = 7.0 nM 8.15
CHEMBL329105 IC50 = 8.0 nM 8.10
CHEMBL92818 IC50 = 13.0 nM 7.89
CHEMBL273302 IC50 = 13.7 nM 7.86
CHEMBL329325 IC50 = 20.0 nM 7.70
CHEMBL92524 IC50 = 30.0 nM 7.52
CHEMBL92032 IC50 = 49.0 nM 7.31
CHEMBL71498 IC50 = 55.0 nM 7.26
CHEMBL323128 IC50 = 95.0 nM 7.02
CHEMBL93909 IC50 = 135.0 nM 6.87