Assay Detail
Binding
CHEMBL880951
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Binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) was determined by HTRF assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.51 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL843 | ROSIGLITAZONE MALEATE | 4.0 | 1 | 7.85 |
| CHEMBL324856 | — | — | 1 | 7.42 |
| CHEMBL421602 | — | — | 1 | 7.33 |
| CHEMBL110295 | — | — | 1 | 7.10 |
| CHEMBL110408 | — | — | 1 | 6.96 |
| CHEMBL430894 | — | — | 1 | 6.96 |
| CHEMBL108905 | — | — | 1 | 6.71 |
| CHEMBL323773 | — | — | 1 | 6.44 |
| CHEMBL326015 | — | — | 1 | 6.25 |
| CHEMBL110353 | — | — | 1 | 5.96 |
| CHEMBL319637 | — | — | 1 | 5.95 |
| CHEMBL110283 | — | — | 1 | 5.50 |
| CHEMBL106256 | — | — | 1 | 5.42 |
| CHEMBL109161 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL843 | ROSIGLITAZONE MALEATE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL324856 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL421602 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL110295 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL110408 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL430894 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL108905 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL323773 | — | Ki | = | 365.0 | nM | 6.44 |
| CHEMBL326015 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL110353 | — | Ki | = | 1090.0 | nM | 5.96 |
| CHEMBL319637 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL110283 | — | Ki | = | 3149.0 | nM | 5.50 |
| CHEMBL106256 | — | Ki | = | 3760.0 | nM | 5.42 |
| CHEMBL109161 | — | Ki | = | 4600.0 | nM | 5.34 |