Assay Detail
Functional
CHEMBL881001
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In vivo antimalarial activity against Plasmodium falciparum W-2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.07 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.66 |
| CHEMBL278291 | WR-148999 | — | 1 | 8.47 |
| CHEMBL96830 | — | — | 1 | 7.89 |
| CHEMBL93291 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL278291 | WR-148999 | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL96830 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL93291 | — | IC50 | = | 58.0 | nM | 7.24 |