Assay Detail
Binding
CHEMBL881228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Aggrecanase 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 4 (CHEMBL2318) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR of highly selective MMP-13 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.07 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427366 | — | — | 1 | 5.36 |
| CHEMBL198262 | — | — | 1 | 5.25 |
| CHEMBL425020 | — | — | 1 | 5.07 |
| CHEMBL194430 | — | — | 1 | 4.84 |
| CHEMBL199241 | — | — | 1 | 4.82 |
| CHEMBL194377 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427366 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL198262 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL425020 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL194430 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL199241 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL194377 | — | IC50 | > | 15000.0 | nM | - |