Assay Detail
Binding
CHEMBL881229
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Inhibitory activity against Fibroblast growth factor receptor 3
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Molecular modeling of wild-type and D816V c-Kit inhibition based on ATP-competitive binding of ellipticine derivatives to tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.18 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26559 | — | — | 1 | 6.40 |
| CHEMBL16699 | ELLIPTINIUM | 2.0 | 1 | 6.30 |
| CHEMBL55137 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26559 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL16699 | ELLIPTINIUM | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL55137 | — | IC50 | = | 1400.0 | nM | 5.85 |