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Assay Detail

CHEMBL881280

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against COX-2; (valus obtained by Kato et al.)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors.
Franke L, Byvatov E, Werz O, Steinhilber D, Schneider P, Schneider G.
J Med Chem (2005) 48 : 6997 -7004
PubMed 16250658 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 7.78 8.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL118 CELECOXIB 4.0 1 8.17
CHEMBL122 ROFECOXIB 4.0 1 7.60
CHEMBL139 DICLOFENAC 4.0 1 7.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL118 CELECOXIB IC50 = 6.8 nM 8.17
CHEMBL122 ROFECOXIB IC50 = 25.0 nM 7.60
CHEMBL139 DICLOFENAC IC50 = 26.0 nM 7.58