Assay Detail
Binding
CHEMBL881350
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In vitro binding affinity against rat cannabinoid receptor 1 using 0.5 nM [3H]CP-55940
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 8.55 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193331 | — | — | 1 | 9.15 |
| CHEMBL68641 | — | — | 1 | 9.05 |
| CHEMBL370009 | — | — | 1 | 8.96 |
| CHEMBL194998 | — | — | 1 | 8.96 |
| CHEMBL364266 | — | — | 1 | 8.92 |
| CHEMBL364223 | — | — | 1 | 8.89 |
| CHEMBL194313 | — | — | 1 | 8.85 |
| CHEMBL195297 | — | — | 1 | 8.77 |
| CHEMBL371328 | — | — | 1 | 8.66 |
| CHEMBL195838 | — | — | 1 | 8.64 |
| CHEMBL194314 | — | — | 1 | 8.40 |
| CHEMBL445392 | — | — | 1 | 8.11 |
| CHEMBL196834 | — | — | 1 | 7.92 |
| CHEMBL196364 | — | — | 1 | 7.91 |
| CHEMBL196648 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193331 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL68641 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL370009 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL194998 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL364266 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL364223 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL194313 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL195297 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL371328 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL195838 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL194314 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL445392 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL196834 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL196364 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL196648 | — | Ki | = | 100.0 | nM | 7.00 |