Assay Detail
Binding
CHEMBL881400
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Inhibitory concentration against c-Jun N-terminal kinase 1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.59 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399167 | — | — | 1 | 7.35 |
| CHEMBL197613 | — | — | 1 | 7.21 |
| CHEMBL194806 | — | — | 1 | 7.15 |
| CHEMBL199136 | — | — | 1 | 7.09 |
| CHEMBL198687 | — | — | 1 | 6.64 |
| CHEMBL197698 | — | — | 1 | 6.61 |
| CHEMBL198821 | — | — | 1 | 6.16 |
| CHEMBL254443 | — | — | 1 | 5.80 |
| CHEMBL440566 | — | — | 1 | 5.27 |
| CHEMBL383177 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399167 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL197613 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL194806 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL199136 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL198687 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL197698 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL198821 | — | IC50 | = | 698.0 | nM | 6.16 |
| CHEMBL254443 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL440566 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL383177 | — | IC50 | > | 10000.0 | nM | - |