Assay Detail
Binding
CHEMBL881407
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Strand transfer inhibitory activity against HIV-1 integrase
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 integrase (CHEMBL3471) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.19 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414850 | — | — | 1 | 8.00 |
| CHEMBL193759 | — | — | 1 | 8.00 |
| CHEMBL368084 | — | — | 1 | 7.70 |
| CHEMBL36070 | — | — | 1 | 7.40 |
| CHEMBL380588 | — | — | 1 | 7.40 |
| CHEMBL421353 | — | — | 1 | 7.30 |
| CHEMBL142072 | — | — | 1 | 7.30 |
| CHEMBL194833 | — | — | 1 | 7.00 |
| CHEMBL320261 | — | — | 1 | 7.00 |
| CHEMBL371471 | — | — | 1 | 6.85 |
| CHEMBL197584 | — | — | 1 | 6.82 |
| CHEMBL197638 | — | — | 1 | 6.75 |
| CHEMBL371867 | — | — | 1 | 6.66 |
| CHEMBL198000 | — | — | 1 | 6.60 |
| CHEMBL108253 | — | — | 1 | 6.46 |
| CHEMBL35842 | — | — | 1 | 6.43 |
| CHEMBL196421 | — | — | 1 | 6.30 |
| CHEMBL108760 | — | — | 1 | 6.28 |
| CHEMBL288097 | — | — | 1 | 6.22 |
| CHEMBL140319 | — | — | 1 | 6.00 |
| CHEMBL108775 | — | — | 1 | 5.89 |
| CHEMBL323204 | — | — | 1 | 5.84 |
| CHEMBL108511 | — | — | 1 | 5.75 |
| CHEMBL3348565 | — | — | 1 | 5.71 |
| CHEMBL438262 | — | — | 1 | 5.70 |
| CHEMBL22197 | — | — | 1 | 5.60 |
| CHEMBL371519 | — | — | 1 | 5.16 |
| CHEMBL108423 | — | — | 1 | 4.94 |
| CHEMBL16326 | — | — | 1 | 4.62 |
| CHEMBL322472 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414850 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL193759 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL368084 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL36070 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL380588 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL421353 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL142072 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL194833 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL320261 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL371471 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL197584 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL197638 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL371867 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL198000 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL108253 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL35842 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL196421 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL108760 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL288097 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL140319 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL108775 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL323204 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL108511 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3348565 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL438262 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL22197 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL371519 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL108423 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL16326 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL322472 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL432788 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL193758 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL371473 | — | IC50 | = | 100000.0 | nM | 4.00 |