Assay Detail
Binding
CHEMBL881498
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Inhibitory concentration against human somatostatin receptor type 5 in CHO-K1 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.22 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | 3.0 | 1 | 9.70 |
| CHEMBL264133 | — | — | 1 | 9.19 |
| CHEMBL440636 | — | — | 1 | 9.00 |
| CHEMBL410110 | — | — | 1 | 8.54 |
| CHEMBL263209 | — | — | 1 | 8.47 |
| CHEMBL269532 | — | — | 1 | 8.25 |
| CHEMBL407676 | — | — | 1 | 8.00 |
| CHEMBL386909 | — | — | 1 | 7.85 |
| CHEMBL3350037 | — | — | 1 | 7.66 |
| CHEMBL441185 | — | — | 1 | 7.52 |
| CHEMBL414316 | — | — | 1 | 7.27 |
| CHEMBL436678 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823872 | SOMATOSTATIN | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL264133 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL440636 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL410110 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL263209 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL269532 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL407676 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL386909 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3350037 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL441185 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL414316 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL436678 | — | IC50 | = | 74.0 | nM | 7.13 |