Assay Detail
Binding
CHEMBL881502
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Inhibitory concentration against COX-2 upon incubation for 15 minutes at 37 degree C
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Extraction and visualization of potential pharmacophore points using support vector machines: application to ligand-based virtual screening for COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.23 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 8.30 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.22 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 7.82 |
| CHEMBL436116 | — | — | 1 | 6.70 |
| CHEMBL371849 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL118 | CELECOXIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL436116 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL371849 | — | IC50 | = | 8000.0 | nM | 5.10 |