Assay Detail
Binding
CHEMBL881704
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Inhibitory activity against human Carbonic anhydrase II (hCA II)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.38 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382075 | — | — | 1 | 9.00 |
| CHEMBL194634 | — | — | 1 | 8.70 |
| CHEMBL365558 | — | — | 1 | 8.40 |
| CHEMBL51668 | — | — | 1 | 8.30 |
| CHEMBL197412 | — | — | 1 | 8.22 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL194350 | — | — | 1 | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL23559 | — | — | 1 | 7.43 |
| CHEMBL23238 | — | — | 1 | 7.40 |
| CHEMBL23796 | — | — | 1 | 7.31 |
| CHEMBL254833 | — | — | 1 | 7.28 |
| CHEMBL193648 | — | — | 1 | 7.19 |
| CHEMBL22374 | — | — | 1 | 7.12 |
| CHEMBL193825 | — | — | 1 | 7.09 |
| CHEMBL363168 | — | — | 1 | 7.00 |
| CHEMBL417648 | — | — | 1 | 6.88 |
| CHEMBL370526 | — | — | 1 | 6.82 |
| CHEMBL283097 | — | — | 1 | 6.67 |
| CHEMBL23285 | — | — | 1 | 6.64 |
| CHEMBL23591 | — | — | 1 | 6.64 |
| CHEMBL278395 | — | — | 1 | 6.63 |
| CHEMBL687 | ACETYLSULFANILAMIDE | — | 1 | 6.61 |
| CHEMBL23417 | — | — | 1 | 6.59 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382075 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL194634 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL365558 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL51668 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL197412 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL194350 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL23559 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL23238 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL23796 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL254833 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL193648 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL22374 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL193825 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL363168 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL417648 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL370526 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL283097 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL23285 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL23591 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL278395 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL687 | ACETYLSULFANILAMIDE | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL23417 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 300.0 | nM | 6.52 |