Assay Detail
Binding
CHEMBL881706
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Inhibitory activity against human Carbonic anhydrase XII (hCA XII)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.51 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL382075 | — | — | 1 | 8.72 |
| CHEMBL197412 | — | — | 1 | 8.62 |
| CHEMBL194634 | — | — | 1 | 8.48 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL370526 | — | — | 1 | 8.00 |
| CHEMBL51668 | — | — | 1 | 7.89 |
| CHEMBL22374 | — | — | 1 | 7.89 |
| CHEMBL194350 | — | — | 1 | 7.75 |
| CHEMBL23559 | — | — | 1 | 7.68 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.66 |
| CHEMBL254833 | — | — | 1 | 7.62 |
| CHEMBL417648 | — | — | 1 | 7.51 |
| CHEMBL193648 | — | — | 1 | 7.48 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 7.43 |
| CHEMBL687 | ACETYLSULFANILAMIDE | — | 1 | 7.31 |
| CHEMBL278395 | — | — | 1 | 7.25 |
| CHEMBL23796 | — | — | 1 | 7.17 |
| CHEMBL193825 | — | — | 1 | 7.12 |
| CHEMBL365558 | — | — | 1 | 7.10 |
| CHEMBL23238 | — | — | 1 | 7.08 |
| CHEMBL23591 | — | — | 1 | 7.07 |
| CHEMBL23417 | — | — | 1 | 6.86 |
| CHEMBL283097 | — | — | 1 | 6.83 |
| CHEMBL23285 | — | — | 1 | 6.60 |
| CHEMBL363168 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL382075 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL197412 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL194634 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL370526 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL51668 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL22374 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL194350 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL23559 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL254833 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL417648 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL193648 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL687 | ACETYLSULFANILAMIDE | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL278395 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL23796 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL193825 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL365558 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL23238 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL23591 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL23417 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL283097 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL23285 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL363168 | — | Ki | = | 348.0 | nM | 6.46 |