Assay Detail
Binding
CHEMBL881945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis detoxification enzyme mycothiol-S-conjugate amidase (MCA)
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mycothiol S-conjugate amidase (CHEMBL3703) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.69 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83747 | PSAMMAPLIN A | — | 2 | 5.55 |
| CHEMBL197081 | — | — | 2 | 4.46 |
| CHEMBL371412 | — | — | 2 | 4.05 |
| CHEMBL194868 | — | — | 2 | - |
| CHEMBL194921 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83747 | PSAMMAPLIN A | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL83747 | PSAMMAPLIN A | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL197081 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL197081 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL371412 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL371412 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL194868 | — | IC50 | = | 185000.0 | nM | - |
| CHEMBL194921 | — | IC50 | = | 2720000.0 | nM | - |
| CHEMBL194868 | — | IC50 | = | 185000.0 | nM | - |
| CHEMBL194921 | — | IC50 | = | 2720000.0 | nM | - |