Assay Detail
Binding
CHEMBL881988
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Percent inhibition against GABAA receptor alpha at a compound concentration of 1 uM
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2093872) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| IC50 | 1 | 7.80 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273481 | MUSCIMOL | 1.0 | 1 | 7.80 |
| CHEMBL197669 | ST1535 | 1.0 | 1 | - |
| CHEMBL196258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273481 | MUSCIMOL | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL197669 | ST1535 | Inhibition | < | 10.0 | % | - |
| CHEMBL196258 | — | Inhibition | < | 10.0 | % | - |