Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL882068

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Effective concentration for inhibition of histone deacetylase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Design and synthesis of phthalimide-type histone deacetylase inhibitors.
Shinji C, Nakamura T, Maeda S, Yoshida M, Hashimoto Y, Miyachi H.
Bioorg Med Chem Lett (2005) 15 : 4427 -4431
PubMed 16137884 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.05 6.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL197774 1 6.83
CHEMBL198140 1 6.75
CHEMBL370695 1 6.73
CHEMBL198556 1 6.60
CHEMBL194509 1 6.54
CHEMBL194851 1 6.39
CHEMBL197949 1 6.32
CHEMBL197480 1 6.12
CHEMBL198324 1 5.68
CHEMBL370525 1 5.68
CHEMBL194730 1 5.42
CHEMBL371304 1 5.38
CHEMBL196424 1 5.18
CHEMBL198555 1 5.10
CHEMBL197992 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL197774 EC50 = 148.0 nM 6.83
CHEMBL198140 EC50 = 177.0 nM 6.75
CHEMBL370695 EC50 = 186.0 nM 6.73
CHEMBL198556 EC50 = 250.0 nM 6.60
CHEMBL194509 EC50 = 291.0 nM 6.54
CHEMBL194851 EC50 = 407.0 nM 6.39
CHEMBL197949 EC50 = 474.0 nM 6.32
CHEMBL197480 EC50 = 763.0 nM 6.12
CHEMBL198324 EC50 = 2080.0 nM 5.68
CHEMBL370525 EC50 = 2090.0 nM 5.68
CHEMBL194730 EC50 = 3790.0 nM 5.42
CHEMBL371304 EC50 = 4160.0 nM 5.38
CHEMBL196424 EC50 = 6630.0 nM 5.18
CHEMBL198555 EC50 = 7890.0 nM 5.10
CHEMBL197992 EC50 = 125000.0 nM -