Assay Detail
Functional
CHEMBL882139
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In vitro cytotoxicity against Chinese hamster V79-derived cell line T78-1 transfected with Escherichia coli B nitroreductase (NTR)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | T78-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.21 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116759 | — | — | 1 | 5.62 |
| CHEMBL325046 | — | — | 1 | 5.05 |
| CHEMBL432797 | — | — | 1 | 4.96 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116759 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL325046 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL432797 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 395000.0 | nM | - |