Assay Detail
Functional
CHEMBL882152
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Inhibitory activity against SKOV3 (human ovarian carcinoma) cell line with Escherichia coli nitroreductase combination after 18 hours drug exposure
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitroaryl phosphoramides as novel prodrugs for E. coli nitroreductase activation in enzyme prodrug therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.23 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144896 | — | — | 1 | 5.92 |
| CHEMBL142795 | — | — | 1 | 5.33 |
| CHEMBL23330 | TRETAZICAR | 2.0 | 1 | 5.33 |
| CHEMBL143069 | — | — | 1 | 5.30 |
| CHEMBL142479 | — | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144896 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL142795 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL23330 | TRETAZICAR | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL143069 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL142479 | — | IC50 | = | 55000.0 | nM | 4.26 |