Assay Detail
Binding
CHEMBL882161
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Compound was tested for inhibition of HIV-1 Y181C reverse transcriptase using dTTP as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.76 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338435 | — | — | 1 | 5.98 |
| CHEMBL338979 | — | — | 1 | 5.72 |
| CHEMBL331912 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338435 | — | Ki | = | 1046.0 | nM | 5.98 |
| CHEMBL338979 | — | Ki | = | 1922.0 | nM | 5.72 |
| CHEMBL331912 | — | Ki | = | 2547.0 | nM | 5.59 |