Assay Detail
Binding
CHEMBL882165
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Concentration required for 50% in vitro inhibition in sheep liver sorbitol dehydrogenase (s-SDH)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.89 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146805 | — | — | 1 | 6.48 |
| CHEMBL151268 | — | — | 1 | 6.46 |
| CHEMBL357712 | — | — | 1 | 6.39 |
| CHEMBL358327 | — | — | 1 | 6.37 |
| CHEMBL423753 | — | — | 1 | 6.32 |
| CHEMBL148935 | — | — | 1 | 6.31 |
| CHEMBL151605 | — | — | 1 | 6.23 |
| CHEMBL148647 | — | — | 1 | 6.13 |
| CHEMBL148822 | — | — | 1 | 6.05 |
| CHEMBL151753 | — | — | 1 | 5.96 |
| CHEMBL348663 | — | — | 1 | 5.96 |
| CHEMBL148835 | — | — | 1 | 5.89 |
| CHEMBL147407 | — | — | 1 | 5.64 |
| CHEMBL148585 | — | — | 1 | 5.58 |
| CHEMBL151033 | — | — | 1 | 5.52 |
| CHEMBL151806 | — | — | 1 | 5.50 |
| CHEMBL148648 | — | — | 1 | 5.50 |
| CHEMBL357720 | — | — | 1 | 5.32 |
| CHEMBL341857 | — | — | 1 | 5.19 |
| CHEMBL422143 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146805 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL151268 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL357712 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL358327 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL423753 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL148935 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL151605 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL148647 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL148822 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL151753 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL348663 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL148835 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL147407 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL148585 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL151033 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL151806 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL148648 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL357720 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL341857 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL422143 | — | IC50 | = | 9400.0 | nM | 5.03 |