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Assay Detail

CHEMBL882453

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for rat Alpha-1A adrenergic receptor using [11C] radiotracer
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Alpha-1A adrenergic receptor (CHEMBL319)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors.
Turolla EA, Matarrese M, Belloli S, Moresco RM, Simonelli P, Todde S, Fazio F, Magni F, Kienle MG, Leopoldo M, Berardi F, Colabufo NA, Lacivita E, Perrone R.
J Med Chem (2005) 48 : 7018 -7023
PubMed 16250661 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.29 5.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL345820 1 5.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL345820 Ki = 5100.0 nM 5.29