Assay Detail
Binding
CHEMBL882471
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Inhibition constant against human 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligand with the compound (10 uM) dissolved in DMSO
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.05 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370859 | — | — | 1 | 6.91 |
| CHEMBL198124 | — | — | 1 | 6.51 |
| CHEMBL197646 | — | — | 1 | 6.47 |
| CHEMBL364061 | — | — | 1 | 6.37 |
| CHEMBL370221 | — | — | 1 | 6.30 |
| CHEMBL198617 | — | — | 1 | 6.23 |
| CHEMBL197664 | — | — | 1 | 6.05 |
| CHEMBL194588 | — | — | 1 | 6.04 |
| CHEMBL194202 | — | — | 1 | 6.01 |
| CHEMBL371753 | — | — | 1 | 5.52 |
| CHEMBL382750 | — | — | 1 | 5.12 |
| CHEMBL371899 | — | — | 1 | 5.01 |
| CHEMBL198123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370859 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL198124 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL197646 | — | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL364061 | — | Ki | = | 429.0 | nM | 6.37 |
| CHEMBL370221 | — | Ki | = | 498.0 | nM | 6.30 |
| CHEMBL198617 | — | Ki | = | 588.0 | nM | 6.23 |
| CHEMBL197664 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL194588 | — | Ki | = | 923.0 | nM | 6.04 |
| CHEMBL194202 | — | Ki | = | 982.0 | nM | 6.01 |
| CHEMBL371753 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL382750 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL371899 | — | Ki | = | 9753.0 | nM | 5.01 |
| CHEMBL198123 | — | Ki | > | 10000.0 | nM | - |