Assay Detail
Binding
CHEMBL882497
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.90 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118105 | — | — | 1 | 8.73 |
| CHEMBL117413 | — | — | 1 | 8.60 |
| CHEMBL334115 | — | — | 1 | 8.54 |
| CHEMBL407427 | — | — | 1 | 8.52 |
| CHEMBL116072 | — | — | 1 | 8.43 |
| CHEMBL299944 | — | — | 1 | 8.20 |
| CHEMBL1793831 | — | — | 1 | 8.05 |
| CHEMBL297624 | — | — | 1 | 6.99 |
| CHEMBL325491 | — | — | 1 | 6.96 |
| CHEMBL112481 | VERAGUENSIN | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118105 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL117413 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL334115 | — | Ki | = | 2.86 | nM | 8.54 |
| CHEMBL407427 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL116072 | — | Ki | = | 3.72 | nM | 8.43 |
| CHEMBL299944 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL1793831 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL297624 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL325491 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL112481 | VERAGUENSIN | Ki | = | 1000.0 | nM | 6.00 |