Assay Detail
Functional
CHEMBL882652
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human NCI-H460 (human lung large cell carcinoma, MDR negative) cell growth
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.47 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295738 | — | — | 1 | 8.74 |
| CHEMBL296406 | — | — | 1 | 8.70 |
| CHEMBL45473 | — | — | 1 | 8.64 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.52 |
| CHEMBL297072 | — | — | 1 | 8.42 |
| CHEMBL296914 | — | — | 1 | 8.14 |
| CHEMBL45512 | — | — | 1 | 8.07 |
| CHEMBL295259 | — | — | 1 | 8.06 |
| CHEMBL46052 | — | — | 1 | 8.04 |
| CHEMBL297848 | — | — | 1 | 7.96 |
| CHEMBL45848 | — | — | 1 | 7.96 |
| CHEMBL295356 | — | — | 1 | 7.92 |
| CHEMBL297677 | — | — | 1 | 7.92 |
| CHEMBL47306 | — | — | 1 | 7.72 |
| CHEMBL295850 | — | — | 1 | 7.64 |
| CHEMBL295644 | — | — | 1 | 7.50 |
| CHEMBL295543 | — | — | 1 | 7.48 |
| CHEMBL45482 | — | — | 1 | 7.47 |
| CHEMBL46441 | — | — | 1 | 7.46 |
| CHEMBL296066 | — | — | 1 | 7.39 |
| CHEMBL49889 | — | — | 1 | 7.29 |
| CHEMBL297846 | — | — | 1 | 7.28 |
| CHEMBL46072 | — | — | 1 | 7.21 |
| CHEMBL45481 | — | — | 1 | 7.20 |
| CHEMBL297236 | — | — | 1 | 7.10 |
| CHEMBL45469 | — | — | 1 | 6.82 |
| CHEMBL46215 | — | — | 1 | 6.77 |
| CHEMBL301341 | — | — | 1 | 6.72 |
| CHEMBL47112 | — | — | 1 | 6.57 |
| CHEMBL48004 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295738 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL296406 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL45473 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL297072 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL296914 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL45512 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL295259 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL46052 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL297848 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL45848 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL295356 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL297677 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL47306 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL295850 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL295644 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL295543 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL45482 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL46441 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL296066 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL49889 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL297846 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL46072 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL45481 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL297236 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL45469 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL46215 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL301341 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL47112 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL48004 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL297018 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL46840 | — | IC50 | = | 707.0 | nM | 6.15 |
| CHEMBL295036 | — | IC50 | = | 8550.0 | nM | 5.07 |