Assay Detail
Functional
CHEMBL882860
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Inhibition of cell growth of SW620 cell lines using cell-based assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.64 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328245 | — | — | 1 | 6.70 |
| CHEMBL91811 | — | — | 1 | 6.63 |
| CHEMBL414220 | — | — | 1 | 6.54 |
| CHEMBL92961 | — | — | 1 | 6.52 |
| CHEMBL90595 | — | — | 1 | 6.52 |
| CHEMBL93784 | — | — | 1 | 6.49 |
| CHEMBL94066 | — | — | 1 | 6.33 |
| CHEMBL329856 | — | — | 1 | 6.28 |
| CHEMBL328977 | — | — | 1 | 6.24 |
| CHEMBL328704 | — | — | 1 | 6.21 |
| CHEMBL327838 | — | — | 1 | 6.03 |
| CHEMBL94062 | — | — | 1 | 5.85 |
| CHEMBL91867 | — | — | 1 | 5.82 |
| CHEMBL93386 | — | — | 1 | 5.78 |
| CHEMBL91009 | — | — | 1 | 5.76 |
| CHEMBL94123 | — | — | 1 | 5.70 |
| CHEMBL93049 | — | — | 1 | 5.68 |
| CHEMBL92731 | — | — | 1 | 5.64 |
| CHEMBL94061 | — | — | 1 | 5.63 |
| CHEMBL91925 | — | — | 1 | 5.62 |
| CHEMBL2112370 | — | — | 1 | 5.58 |
| CHEMBL94068 | — | — | 1 | 5.57 |
| CHEMBL2112369 | — | — | 1 | 5.54 |
| CHEMBL94109 | — | — | 1 | 5.38 |
| CHEMBL285063 | — | — | 1 | 5.38 |
| CHEMBL92356 | — | — | 1 | 5.34 |
| CHEMBL442754 | — | — | 1 | 5.23 |
| CHEMBL93783 | — | — | 1 | 5.12 |
| CHEMBL93537 | — | — | 1 | 5.07 |
| CHEMBL419501 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328245 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL91811 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL414220 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL92961 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL90595 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL93784 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL94066 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL329856 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL328977 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL328704 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL327838 | — | IC50 | = | 945.0 | nM | 6.03 |
| CHEMBL94062 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL91867 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL93386 | — | IC50 | = | 1663.0 | nM | 5.78 |
| CHEMBL91009 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL94123 | — | IC50 | = | 2015.0 | nM | 5.70 |
| CHEMBL93049 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL92731 | — | IC50 | = | 2282.0 | nM | 5.64 |
| CHEMBL94061 | — | IC50 | = | 2336.0 | nM | 5.63 |
| CHEMBL91925 | — | IC50 | = | 2387.0 | nM | 5.62 |
| CHEMBL2112370 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL94068 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL2112369 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL94109 | — | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL285063 | — | IC50 | = | 4133.0 | nM | 5.38 |
| CHEMBL92356 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL442754 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL93783 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL93537 | — | IC50 | = | 8470.0 | nM | 5.07 |
| CHEMBL419501 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL92902 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL316127 | — | IC50 | = | 10680.0 | nM | 4.97 |
| CHEMBL93754 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL92882 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL91748 | — | IC50 | = | 12140.0 | nM | 4.92 |
| CHEMBL329642 | — | IC50 | = | 12540.0 | nM | 4.90 |
| CHEMBL93464 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL92086 | — | IC50 | = | 20700.0 | nM | 4.68 |