Assay Detail
Binding
CHEMBL882878
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration in transactivation assay using a chimeric LXR construct in HEK293 cells for LXRbeta receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.71 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191965 | — | — | 1 | 8.00 |
| CHEMBL194409 | — | — | 1 | 5.42 |
| CHEMBL365544 | — | — | 1 | - |
| CHEMBL427183 | — | — | 1 | - |
| CHEMBL196106 | — | — | 1 | - |
| CHEMBL194192 | — | — | 1 | - |
| CHEMBL426289 | — | — | 1 | - |
| CHEMBL424831 | — | — | 1 | - |
| CHEMBL194679 | — | — | 1 | - |
| CHEMBL194573 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191965 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL194409 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL365544 | — | EC50 | < | 3.0 | nM | - |
| CHEMBL427183 | — | EC50 | - | nM | - | |
| CHEMBL196106 | — | EC50 | - | nM | - | |
| CHEMBL194192 | — | EC50 | - | nM | - | |
| CHEMBL426289 | — | EC50 | - | nM | - | |
| CHEMBL424831 | — | EC50 | - | nM | - | |
| CHEMBL194679 | — | EC50 | - | nM | - | |
| CHEMBL194573 | — | EC50 | - | nM | - |