Assay Detail
Binding
CHEMBL882906
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Inhibitory concentration against histamine H1 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Designed multiple ligands. An emerging drug discovery paradigm.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.37 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330366 | — | — | 1 | 8.52 |
| CHEMBL91397 | RUPATADINE | 4.0 | 1 | 8.41 |
| CHEMBL95051 | — | — | 1 | 7.23 |
| CHEMBL10971 | SCH-37370 | — | 1 | 7.00 |
| CHEMBL998 | LORATADINE | 4.0 | 1 | 6.54 |
| CHEMBL93556 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330366 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL91397 | RUPATADINE | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL95051 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL10971 | SCH-37370 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL998 | LORATADINE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL93556 | — | IC50 | = | 309.0 | nM | 6.51 |