Assay Detail
Binding
CHEMBL882907
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Inhibitory concentration against neutral endopeptidase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Designed multiple ligands. An emerging drug discovery paradigm.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.16 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198316 | — | — | 1 | 10.10 |
| CHEMBL372307 | — | — | 1 | 8.10 |
| CHEMBL196902 | — | — | 1 | 8.03 |
| CHEMBL287896 | — | — | 1 | 6.40 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198316 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL372307 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL196902 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL287896 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 830000.0 | nM | - |