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Assay Detail

CHEMBL882912

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration in LXRSPA alpha binding assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Oxysterols receptor LXR-alpha (CHEMBL2808)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis.
Liu W, Chen S, Dropinski J, Colwell L, Robins M, Szymonifka M, Hayes N, Sharma N, MacNaul K, Hernandez M, Burton C, Sparrow CP, Menke JG, Singh SB.
Bioorg Med Chem Lett (2005) 15 : 4574 -4578
PubMed 16125384 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.59 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL365544 1 9.00
CHEMBL191965 1 8.70
CHEMBL196335 1 7.52
CHEMBL372612 1 7.30
CHEMBL371990 1 7.05
CHEMBL194642 1 7.00
CHEMBL194409 1 6.89
CHEMBL199255 1 6.85
CHEMBL194353 1 6.70
CHEMBL194733 1 6.70
CHEMBL382942 1 6.57
CHEMBL194679 1 6.54
CHEMBL370175 1 6.52
CHEMBL197522 1 6.46
CHEMBL196340 1 6.44
CHEMBL194573 1 6.38
CHEMBL365750 1 6.31
CHEMBL197265 1 6.12
CHEMBL194866 1 5.78
CHEMBL427183 1 5.55
CHEMBL196145 1 5.53
CHEMBL424831 1 5.51
CHEMBL426289 1 5.42
CHEMBL194192 1 5.30
CHEMBL196106 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL365544 IC50 = 1.0 nM 9.00
CHEMBL191965 IC50 = 2.0 nM 8.70
CHEMBL196335 IC50 = 30.0 nM 7.52
CHEMBL372612 IC50 = 50.0 nM 7.30
CHEMBL371990 IC50 = 90.0 nM 7.05
CHEMBL194642 IC50 = 100.0 nM 7.00
CHEMBL194409 IC50 = 130.0 nM 6.89
CHEMBL199255 IC50 = 140.0 nM 6.85
CHEMBL194353 IC50 = 200.0 nM 6.70
CHEMBL194733 IC50 = 200.0 nM 6.70
CHEMBL382942 IC50 = 270.0 nM 6.57
CHEMBL194679 IC50 = 290.0 nM 6.54
CHEMBL370175 IC50 = 300.0 nM 6.52
CHEMBL197522 IC50 = 350.0 nM 6.46
CHEMBL196340 IC50 = 360.0 nM 6.44
CHEMBL194573 IC50 = 420.0 nM 6.38
CHEMBL365750 IC50 = 490.0 nM 6.31
CHEMBL197265 IC50 = 750.0 nM 6.12
CHEMBL194866 IC50 = 1670.0 nM 5.78
CHEMBL427183 IC50 = 2800.0 nM 5.55
CHEMBL196145 IC50 = 2930.0 nM 5.53
CHEMBL424831 IC50 = 3100.0 nM 5.51
CHEMBL426289 IC50 = 3800.0 nM 5.42
CHEMBL194192 IC50 = 5060.0 nM 5.30
CHEMBL196106 IC50 > 15000.0 nM -