Assay Detail
Functional
CHEMBL883258
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Effective dose to achieve 50% protection of C8166 cells acutely infected with HIV-2 strain IIIB
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.46 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.22 |
| CHEMBL60734 | — | — | 1 | 6.60 |
| CHEMBL433480 | — | — | 1 | 6.43 |
| CHEMBL60203 | — | — | 1 | 5.55 |
| CHEMBL293201 | — | — | 1 | 5.52 |
| CHEMBL439750 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL60734 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL433480 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL60203 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL293201 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL439750 | — | EC50 | = | 105000.0 | nM | - |