Assay Detail
Functional
CHEMBL883271
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Activity against HIV-1 in CEM/TK cells (in vitro)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-TK(+) |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.13 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45803 | — | — | 1 | 7.60 |
| CHEMBL49588 | — | — | 1 | 7.22 |
| CHEMBL107184 | — | — | 1 | 7.12 |
| CHEMBL3350117 | — | — | 1 | 6.96 |
| CHEMBL295461 | — | — | 1 | 6.96 |
| CHEMBL48644 | — | — | 1 | 6.48 |
| CHEMBL48607 | — | — | 1 | 6.48 |
| CHEMBL48416 | — | — | 1 | 6.40 |
| CHEMBL300889 | — | — | 1 | 5.40 |
| CHEMBL48229 | — | — | 1 | 5.16 |
| CHEMBL49313 | — | — | 1 | 5.07 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 4.48 |
| CHEMBL49515 | — | — | 1 | 4.32 |
| CHEMBL49371 | — | — | 1 | - |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45803 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL49588 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL107184 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3350117 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL295461 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL48644 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL48607 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL48416 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL300889 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL48229 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL49313 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL991 | STAVUDINE | EC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL49515 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL49371 | — | EC50 | > | 250000.0 | nM | - |
| CHEMBL129 | ZIDOVUDINE | EC50 | > | 100000.0 | nM | - |