Assay Detail
Binding
CHEMBL883496
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In vitro concentration that causes 50% inhibition of carbonic anhydrase carbonate hydro-lyase (EC.4.2.1.1) isolated from bovine erythrocyte
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis of 2-substituted-1,3,4-thiadiazole-5-sulphonamides as novel water-soluble inhibitors of carbonic anhydrase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.38 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130950 | — | — | 1 | 8.30 |
| CHEMBL129880 | — | — | 1 | 8.15 |
| CHEMBL335243 | — | — | 1 | 8.10 |
| CHEMBL336554 | — | — | 1 | 8.05 |
| CHEMBL131496 | — | — | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.80 |
| CHEMBL133619 | — | — | 1 | 7.52 |
| CHEMBL91302 | — | — | 2 | 6.43 |
| CHEMBL129895 | — | — | 2 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130950 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL129880 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL335243 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL336554 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL131496 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL133619 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL91302 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL91302 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL129895 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL129895 | — | IC50 | = | 570.0 | nM | 6.24 |