Assay Detail

CHEMBL883544

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Functional

Cytotoxicity against NCI tumor panel, NCI-H 23 non small-cell lung cancer cell line

ChEMBL ↗

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Target

NCI-H23 (CHEMBL614997) ↗

Open DB target context

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NCI-H23 (CHEMBL614997) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NCI-H23

CHEMBL614997

Anchored from Assay target.

Protein identity NCI-H23

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	NCI-H23
Confidence	1 — Organism
Curated By	Intermediate

Target

NCI-H23 (CHEMBL614997) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and preliminary biological evaluations of CC-1065 analogues: effects of different linkers and terminal amides on biological activity.

Wang Y, Yuan H, Ye W, Wright SC, Wang H, Larrick JW.
J Med Chem (2000) 43 : 1541 -1549
PubMed 10780911 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.87	8.87

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL38957	—	—	1	8.87

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL38957	—	IC50	=	1.36	nM	8.87