Assay Detail
Binding
CHEMBL883549
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Tested in vitro for inhibition of neutral endopeptidase (NEP)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual metalloprotease inhibitors. I. constrained peptidomimetics of mercaptoacyl dipeptides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.18 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51389 | — | — | 1 | 9.22 |
| CHEMBL51780 | — | — | 1 | 9.00 |
| CHEMBL301751 | — | — | 1 | 8.92 |
| CHEMBL51438 | — | — | 1 | 8.77 |
| CHEMBL51498 | — | — | 1 | 8.68 |
| CHEMBL299441 | — | — | 1 | 8.66 |
| CHEMBL301364 | — | — | 1 | 8.62 |
| CHEMBL54036 | — | — | 1 | 8.51 |
| CHEMBL50559 | — | — | 1 | 8.28 |
| CHEMBL299639 | — | — | 1 | 8.21 |
| CHEMBL299181 | — | — | 1 | 8.18 |
| CHEMBL298388 | — | — | 1 | 7.19 |
| CHEMBL52733 | — | — | 1 | 7.08 |
| CHEMBL53879 | — | — | 1 | 6.93 |
| CHEMBL287896 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51389 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL51780 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL301751 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL51438 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL51498 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL299441 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL301364 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL54036 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL50559 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL299639 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL299181 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL298388 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL52733 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL53879 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL287896 | — | IC50 | = | 400.0 | nM | 6.40 |