Assay Detail
Binding
CHEMBL883668
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Inhibition constant against aromatase protein from human placental microsomes using [1-beta-3H]-androstenedione; Competitive inhibition
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of new A,D-ring modified steroids as aromatase inhibitors: design, synthesis, and biological activity evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.93 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1629802 | — | — | 1 | 7.42 |
| CHEMBL194641 | — | — | 1 | 7.30 |
| CHEMBL1630280 | — | — | 1 | 6.83 |
| CHEMBL197451 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1629802 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL194641 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1630280 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL197451 | — | Ki | = | 660.0 | nM | 6.18 |