Assay Detail
Functional
CHEMBL883722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determined by phosphoinositide hydrolysis assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.56 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65547 | PSILOCIN | 2.0 | 1 | 7.62 |
| CHEMBL198124 | — | — | 1 | 7.50 |
| CHEMBL197664 | — | — | 1 | 6.20 |
| CHEMBL197646 | — | — | 1 | 6.02 |
| CHEMBL194378 | PSILOCYBIN | 3.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65547 | PSILOCIN | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL198124 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL197664 | — | EC50 | = | 633.0 | nM | 6.20 |
| CHEMBL197646 | — | EC50 | = | 949.0 | nM | 6.02 |
| CHEMBL194378 | PSILOCYBIN | EC50 | = | 3475.0 | nM | 5.46 |