Assay Detail
Functional
CHEMBL883798
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Antiproliferative activity measured against A427 human lung carcinoma
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-427 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.36 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348711 | — | — | 1 | 10.64 |
| CHEMBL345989 | — | — | 1 | 10.51 |
| CHEMBL151912 | — | — | 1 | 10.00 |
| CHEMBL150850 | — | — | 1 | 9.44 |
| CHEMBL345998 | — | — | 1 | 9.21 |
| CHEMBL150195 | — | — | 1 | 8.11 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.62 |
| CHEMBL149851 | — | — | 1 | - |
| CHEMBL358471 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348711 | — | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL345989 | — | IC50 | = | 0.031 | nM | 10.51 |
| CHEMBL151912 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL150850 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL345998 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL150195 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL149851 | — | IC50 | = | 0.0083 | nM | - |
| CHEMBL358471 | — | IC50 | = | 0.00081 | nM | - |